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We show that E6 and E7 inhibited the activity of the transcription factor NFκB in response to a range of anti-viral PRR ligands including the putative TLR7 ligand imiquimod.

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In some embodiments, the treatment cycle includes five days in which the IRM compound is administered and two days in which the IRM compound is not administered.

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Although not evaluated in this study, differences in expression levels of TLRs or other receptors that interact with Leishmania, the maturation stage (), and the functional integrity of permanent cell lines () may account for differences observed in the responses to parasite opsonization elicited in primary macrophages and macrophage cell lines.

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The elucidation of this process may help to explain why keloid scars spread beyond the margins of the original wound, while hypertrophic scars, in which the immune cell infiltrate decreases over time, remain within the original wound margins and often regress over time.

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Although treatment varies from pure trichloroacetic acid, cryotherapy to electrodessication, we prefer simple curettage or excisional surgery.

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During the domicile periods of initiation (Day 1), and end of treatment (Day 20-21) visits, serum PK samples are collected predose and at planned time points through 24 hours post dose.

It also allows the caregiver at one month follow-up evaluation an opportunity to prescribe analgesics or, if a very intense reaction occurs, to continue treatment with once daily 5-FU rather than increasing the treatment to twice daily.

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