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The ability of selegiline to increase dopaminergic responses in rats has been explained by the amphetamine-like properties of L-methamphetamine, a major metabolite of selegiline.

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One case of hypertensive crisis has been reported in a patient taking the recommended doses of selegiline and a sympathomimetic medication (ephedrine).

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Defects in thinking, memory, language, and problem solving skills may occur early on in untreated patients or late in the course of the disease.

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Anticholinergic medications (such as trihexyphenidyl or benztropin) and levodopa may ameliorate both conditions, and deep brain stimulation (DBS) surgery is a surgical treatment for both, although the final brain target may vary.

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