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Johnson, maker of the antipsychotic drug Risperdal, owes hundreds of millions of dollars to several states over improper marketing of the medication and for encouraging doctors to prescribe it for non-approved uses, but because the case was settled in court the company's CEO, Alex Gorsky, won't have to testify about allegations his company's drug caused some young boys to grow breasts, among others.

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It can also help prevent suicide in people likely to harm themselves and reduce aggression and the desire to hurt others.

Individuals are often put on an antipsychotic after a psychotic break, or after other medications have been tried and have been ineffective.

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In patients with remitted first or multiple episodes, APA recommends either indefinite maintenance therapy or gradual discontinuance of the antipsychotic with close follow-up and a plan to reinstitute treatment upon symptom recurrence.

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Antipsychotic drug treatment is a key component of schizophrenia treatment algorithms recommended by the National Institute of Health and Clinical Excellence (NICE), the American Psychiatric Association, and the British Society for Psychopharmacology.

The safety and effectiveness of generic drugs are established by the fact that all of them go through the FDA review and approval procedure.

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Several of the early trials in the Accutane litigation have resulted in multi-million dollar awards of damages for individuals diagnosed with Inflammatory Bowel Disease or other problems from Accutane.

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Risperdal is among the most prescribed psychiatric medications.

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EPS is an often rare group of side effects that may cause restless movement of the legs, trembling fingers or hands, shuffling gait, tight rigid muscles, or painful involuntary muscle cramps or spasms.

Janssen Pharmaceutical's Risperdal trail a month earlier, in February.

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Patients with risk factors for diabetes mellitus (eg, obesity, family history of diabetes) who are starting treatment with atypical antipsychotics should undergo fasting blood glucose testing at the beginning of treatment.

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As for the Risperdal-related lawsuits, Frenze says, “Janssen will continue to defend itself in the ongoing litigation and will try cases where appropriate.

Geriatric patients with dementia-related psychosis treated with either conventional or atypical antipsychotic agents are at an increased risk of death; increased incidence of cerebrovascular events also observed with certain atypical antipsychotic agents.

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All they had was the boy as he now looked, years later.

Janssen instructed its sales representatives to call on child psychiatrists, as well as mental health facilities that primarily treated children, and to market Risperdal as safe and effective for symptoms of various childhood disorders, such as attention deficit hyperactivity disorder, oppositional defiant disorder, obsessive-compulsive disorder and autism.

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The analysis takes roughly 20 cases into account and was published in November of 2003 by the Journal of Clinical Psychiatry.


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