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Patients who were assigned as symptomatic may have had only one biliary colic, years before treatment started, whereas patients in the current study had an average of 13 biliary colics in the 12 months before the study.

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Pre-defined secondary endpoints were: (1) gallstone complications, (2) episodes of non-severe right upper quadrant or midline epigastric pain, (3) (non-prescription) analgesics taken for biliary pain.

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