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When culture results become available clinicians should be prepared to escalate treatment by selecting a higher-tier drug, or de-escalate treatment to a lower-tier drug, as indicated.

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The enzymes involved in the aldehyde-generating steps of these processes are 2-hydroxyacyl-CoA lyase (HACL1) and sphingosine-1-phosphate lyase (SGPL1), respectively.

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Graves CE, Harrison MR, Padilla BE. Minimally invasive fetal surgery. Clin Perinatol.

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Pseudopyodermas are not real pyodermas since infection plays only a secondary role and anti-infectious therapy is not effective.

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Children with acute kidney infection are treated with various antibiotics including oral cefixime (Suprax) or a short course (2 to 4 days) of an intravenous (IV) antibiotic (typically gentamicin, given in one daily dose).

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Generally, a combination of two or more antimicrobial agents is selected to achieve one or more of the following goals: to attain the broadest spectrum possible of activity for empirical therapy of potentially infected persons; to minimize drug toxicity by using relatively low doses of two or more agents with additive efficacies but independent toxicities; to minimize the emergence of strains resistant to a single agent; and to exploit the possibility of synergistic inhibitory or bactericidal activities ().

Jung KY, Takeda M, Shimoda M, Narikawa S, Tojo A, Kim DK, Chairoungdua A, Choi BK, Kusuhara H, Sugiyama Y, et al.

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Mari M. Kitahata, of the University of Washington, Harborview Medical Center, in Seattle.

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Manifestations include a Coombs-positive non-acute hemolytic anemia and usually occur in a small percentage of patients receiving increased doses in intravenous penicillin for a prolonged period of time ().

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The penicillins, derived from species of the fungus Penicillium or manufactured semisynthetically, consist of a thiazolidine ring fused to a beta-lactam ring connected to side chains; these agents exert their action by inhibiting mucopeptide synthesis in bacterial plasma walls during multiplication of the organisms.

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The fourth generation are indicated for the empirical treatmentof nosocomial infections where antibiotic resistance due toextended spectrum β-lactamases are anticipated.

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