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Dosage adjustment of such drugs is not necessary when they are coadministered with pantoprazole.

Continued therapy with pantoprazole 20 mg daily for a further 6 months maintained a remission rate of 80% at 1 year, whereas switching to placebo for the last 6 months of the trial resulted in a remission rate of 30% ().

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Two of these were taken into consideration in the current review as well (; ) but also used data on file from the manufacturer of esomeprazole.

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For major reactions, the patient should contact the physician immediately.

As with any medication and treatment regimen undertaken for gastric-related conditions, they must be taken only as directed, and side effects and drug interactions can hamper their effectiveness or cause complications.

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When used to treat ulcers, rabeprazole is taken after the morning meal.

Keep pantoprazole, as well as syringes and needles, out of the reach of children and away from pets.

PPI therapy had significantly less recurrent ulcer bleeding than placebo at a median of 12 months (1.

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Histamine 2 antagonists and PPIs have largely replaced antacids as primary treatment for most acid-peptic disorders; nevertheless, there is still a role for their use as they are inexpensive, readily available, and safe in most populations.

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Not all possible interactions are listed in this medication guide.

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In children who are critically ill, oral administration of acid suppressive agents is relatively contraindicated therefore an intravenous alternative such as intravenous pantoprazole is imperative.

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Anecdotally, for active bleeding, injection of epinephrine may slow or stop bleeding allowing improved visualization for application of subsequent therapy.

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NG aspirate in hospital) endoscopy within 12 h may be considered to potentially improve clinical outcomes (Conditional recommendation, low-quality evidence).

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Two hundred and seventy-four patients with endoscopically proven reflux esophagitis in the Affiliated Hospital of Yanbian University from January, 2006 to September, 2007 and the Affiliated Hospital of Hainan Medical College from October, 2007 to November, 2008 were included in the study.

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Evidence to date indicates that any morphological changes in gastric endocrine cells are minimal, self-limiting, nondysplastic and non-neoplastic, suggesting that hypergastrinemia observed during PPI therapy has little clinical significance ().

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Due to its effects on gastric acid secretion, Pantoprazole can reduce the absorption of drugs where gastric pH is an important determinant of their bioavailability.

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Thus, there are data to support that esomeprazole treatment is associated with improvement in health-related QoL indices in patients with GERD, at least compared with ranitidine.

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PO Recommended starting dosage is 40 mg twice daily, adjusting the dose to the patient's needs and continuing therapy as long as clinically indicated.

Prilosec, Nexium, Prevacid, Protonix, AcipHex, Dexilant Kapidex, Zegerid) is not meant to state or imply that the company acted illegally or improperly or that the product is unsafe or defective; rather only that an investigation may be, is or was being conducted to determine whether legal rights have been violated.

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Table 1: Recommended Dosing Schedule for Pantoprazole Sodium Delayed-release Tablets For adult patients who have not healed after 8 weeks of treatment, an additional 8-week course of pantoprazole sodium delayed-release tablets may be considered.

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Cremer M, Lambert R, Lamers CB, Delle Fave G, Maier C "A double-blind study of pantoprazole and ranitidine in treatment of acute duodenal ulcer.

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